H.L. Rutledge, B.D. Cook, H.P.M. Nguyen, M.A. Herzik Jr., F.A. Tezcan. Structures of the nitrogenase complex prepared under catalytic turnover conditions, Science (2022). [PDF] [Free access]

K. Han*, Y. Na*, L. Zhang, F.A. Tezcan. Dynamic, Polymer-Integrated Crystals for Efficient, Reversible Protein Encapsulation, J. Am. Chem. Soc. (2022). [PDF]

A. Kakkis, E. Golub, T.S. Choi, F.A. Tezcan. Redox- and metal-directed structural diversification in designed metalloprotein assemblies, Chem. Commun. (2022). [PDF]

T.S. Choi, F.A. Tezcan. Overcoming universal restrictions on metal selectivity by protein design, Nature (2022). [PDF]

J. Zhu*, L. Samperisi*, M. Kalaj, J.A. Chiong, J.B. Bailey, Z. Zhang, C. Yu, R.E. Sikma, X. Zou, S.M. Cohen, Z. Huang, F.A. Tezcan. Metal-hydrogen-pi-bonded organic frameworks, Dalton Trans. (2022). [PDF]

J. Zhu*, N. Avakyan*, A. Kakkis, A.M. Hoffnagle, K. Han, Y. Li, Z. Zhang, T.S. Choi, Y. Na, C. Yu, F.A. Tezcan. Protein assembly by design, Chem. Rev. (2021). [PDF]

J.L. Prelesnik*, R.G. Alberstein*, S. Zhang, H. Pyles, D. Baker, J. Pfaendtner, J.J. De Yoreo, F.A. Tezcan, R.C. Remsing, C.J. Mundy. Ion-dependent protein–surface interactions from intrinsic solvent response, Proc. Natl. Acad. Sci. USA (2021). [PDF]

R.H. Subramanian, J. Zhu, J.B. Bailey, J.A. Chiong, Y. Li, E. Golub, F.A. Tezcan. Design of metal-mediated protein assemblies via hydroxamic acid functionalities, Nat. Protoc. (2021). [PDF]

K. Han, J.B. Bailey, L. Zhang, F.A. Tezcan. Anisotropic Dynamics and Mechanics of Macromolecular Crystals Containing Lattice-Patterned Polymer Networks, J. Am. Chem. Soc. (2020). [PDF]

J.B. Bailey, F.A. Tezcan. Tunable and Cooperative Thermomechanical Properties of Protein–Metal–Organic Frameworks, J. Am. Chem. Soc. (2020). [PDF]

A. Kakkis, D. Gagnon, J. Esselborn, R.D. Britt, F.A. Tezcan. Metal-Templated Design of Chemically Switchable Protein Assemblies with High-Affinity Coordination Sites, Angew. Chem. Int. Ed. (2020). [PDF]

K.C. Bentz, K. Gnanasekaran, J.B. Bailey, S. Ayala, F.A. Tezcan, N.C. Gianneschi, S.M. Cohen. Inside polyMOFs: layered structures in polymer-based metal–organic frameworks, Chem. Sci. (2020). [PDF]

R. Subramanian, Y. Suzuki, L. Tallorin, S. Sahu, M.P. Thompson, N.C. Gianneschi, M.D. Burkart, F.A. Tezcan. Enzyme-Directed Functionalization of Designed, Two-Dimensional Protein Lattices, Biochemistry (2020). [PDF]

J.A. Chiong*, J. Zhu*, J.B. Bailey*, M. Kalaj, R. Subramanian, W. Xu, S.M. Cohen, F.A. Tezcan. An Exceptionally Stable Metal-Organic Framework Constructed from Chelate-based Metal-Organic Polyhedra, J. Am. Chem. Soc. (2020). [PDF]

S. Zhang*, R.G. Alberstein*, J.J. De Yoreo, F.A. Tezcan. Assembly of a patchy protein into variable 2D lattices via tunable, multiscale interactions, Nat. Commun. (2020). [Preprint] [PDF]

H.L. Rutledge, F.A. Tezcan. Electron Transfer in Nitrogenase, Chem. Rev. (2020). [PDF]

E. Golub, R.H. Subramanian, J. Esselborn, R.G. Alberstein, J.B. Bailey, J.A. Chiong, X. Yan, T. Booth, T.S. Baker, F.A. Tezcan. Constructing protein polyhedra via orthogonal chemical interactions, Nature (2020). [PDF]

H.L Rutledge, J. Rittle, L.M. Williamson, W.A. Xu, D.M. Gagnon, F.A. Tezcan. Redox-dependent metastability of the nitrogenase P-cluster, J. Am. Chem. Soc. (2019). [PDF]

J. Rittle, M.J. Field, M.T. Green, F.A. Tezcan. An efficient, step-economical strategy for the design of functional metalloproteins, Nat. Chem. (2019). [PDF]

L.A. Churchfield, F.A. Tezcan. Design and Construction of Functional Supramolecular Metalloprotein Assemblies, Acc. Chem. Res. (2019). [PDF]

R.H. Subramanian*, S.J. Smith*, R.G. Alberstein, J.B. Bailey, L. Zhang, G. Cardone, L. Suominen, M. Chami, H. Stahlberg, T.S. Baker, F.A. Tezcan. Self-Assembly of a Designed Nucleoprotein Architecture through Multimodal Interactions, ACS Cent. Sci. (2018). [PDF]

L.A. Churchfield, R.G. Alberstein, L.M. Williamson, F.A. Tezcan. Determining the Structural and Energetic Basis of Allostery in a De Novo Designed Metalloprotein Assembly, J. Am. Chem. Soc. (2018). [PDF]

L. Zhang, J.B. Bailey, R.H. Subramanian, F.A. Tezcan. Hyperexpandable, self-healing macromolecular crystals with integrated polymer networks, Nature (2018). [PDF]

R. Alberstein, Y. Suzuki, F. Paesani, F.A. Tezcan. Engineering the entropy-driven free-energy landscape of a dynamic nanoporous protein assembly, Nat. Chem. (2018). [PDF]

W.J. Song, J. Yu, F.A. Tezcan. Importance of scaffold flexibility/rigidity in the design and directed evolution of artificial metallo-β-lactamases, J. Am. Chem. Soc. (2017). [PDF]

J.B. Bailey, L. Zhang, J.A. Chiong, S. Ahn, F.A. Tezcan. Synthetic Modularity of Protein–Metal–Organic Frameworks, J. Am. Chem. Soc. (2017). [PDF]

L.A. Churchfield, A. George, F.A. Tezcan. Repurposing proteins for new bioinorganic functions, Essays Biochem. (2017). [PDF]

S.A. Chabolla, C.W. Machan, J. Yin, E.A. Dellamary, S. Sahu, N.C. Gianneschi, M.K.Gilson, F.A. Tezcan, C.P. Kubiak. Bio-inspired CO2 reduction by a rhenium tricarbonyl bipyridine-based catalyst appended to amino acids and peptidic platforms: incorporating proton relays and hydrogen-bonding functional groups, Farad. Discuss. (2017). [PDF]

F.E.H. Katz, X. Shi, C.P. Owens, S. Joseph, F.A. Tezcan. Determination of nucleoside triphosphatase activities from measurement of true inorganic phosphate in the presence of labile phosphate compounds, Anal. Biochem. (2017). [PDF]

L.A. Churchfield, F. Medina-Morales, J.D. Brodin, A. Perez, F.A. Tezcan. De Novo Design of an Allosteric Metalloprotein Assembly with Strained Disulfide Bonds, J. Am. Chem. Soc. (2016). [PDF]

C.P. Owens, F.E.H. Katz, C.H. Carter, V.F. Oswald, F.A. Tezcan. Tyrosine-coordinated P-cluster in G. diazotrophicus nitrogenase: Evidence for the importance of O-based ligands in conformationally gated electron transfer, J. Am. Chem. Soc. (2016). [PDF]

J.B. Bailey, R.H. Subramanian, L.A. Churchfield, F.A. Tezcan. Chapter Eleven – Metal-Directed Design of Supramolecular Protein Assemblies, Meth. Enzym. (2016). [PDF]

F.E.H. Katz, C.P. Owens, F.A. Tezcan. Electron Transfer Reactions in Biological Nitrogen Fixation, Isr. J. Chem. (2016). [PDF]

Y. Suzuki, G. Cardone, D. Restrepo, P.D. Zavattieri, T.S. Baker, F.A. Tezcan. Self-assembly of coherently dynamic, auxetic, two-dimensional protein crystals, Nature (2016). [PDF]

S.J. Smith, R.J. Radford, R.H. Subramanian, B.R. Barnett, J.S. Figueroa, F.A. Tezcan. Tunable helicity, stability and DNA-binding properties of short peptides with hybrid metal coordination motifs, Chem. Sci. (2016). [PDF]

C.P. Owens, F.E.H. Katz, C.H. Carter, M.A. Luca, F.A. Tezcan. Evidence for Functionally Relevant Encounter Complexes in Nitrogenase Catalysis, J. Am. Chem. Soc. (2015). [PDF]

P.A. Sontz*, J.B. Bailey*, S. Ahn, F.A. Tezcan. A Metal Organic Framework with Spherical Protein Nodes: Rational Chemical Design of 3D Protein Crystals, J. Am. Chem. Soc. (2015). [PDF]

J.D. Brodin*, S.J. Smith*, J.R. Carr, F.A. Tezcan. Designed, Helical Protein Nanotubes with Variable Diameters from a Single Building Block, J. Am. Chem. Soc. (2015). [PDF]

F.A. Tezcan, J.T. Kaiser, J.B. Howard, D.C. Rees. Structural Evidence for Asymmetrical Nucleotide Interactions in Nitrogenase, J. Am. Chem. Soc. (2014). [PDF]

W.J. Song, F.A. Tezcan. A designed supramolecular protein assembly with in vivo enzymatic activity, Science 346, 1525-1528 (2014). [PDF]

C.W. Machan, S.A. Chabolla, J. Yin, M.K. Gilson, F.A. Tezcan, C.P. Kubiak. Supramolecular Assembly Promotes the Electrocatalytic Reduction of Carbon Dioxide by Re(I) Bipyridine Catalysts at a Lower Overpotential, J. Am. Chem. Soc. 136, 14598-14607 (2014). [PDF]3.

S.A. Chabolla, E.A. Dellamary, C.W. Machan, F.A. Tezcan, C.P. Kubiak. Combined steric and electronic effects of positional substitution on dimethyl-bipyridine rhenium(I)tricarbonyl electrocatalysts for the reduction of CO2, Inorg. Chim. Acta 422, 109-113 (2014). [PDF]

P.A. Sontz*, W.J. Song*, F. A. Tezcan. Interfacial metal coordination in engineered protein and peptide assemblies, Curr. Opin. Chem. Biol. 19, 42-49 (2014). [PDF]

W.J. Song*, P.A. Sontz*, X.I. Ambroggio, F.A. Tezcan. Metals in protein-protein interfaces, Annu. Rev. Biophys.  43, 409-431 (2014). [PDF]

J.D. Brodin, J.R. Carr, P.A. Sontz, F.A. Tezcan. Exceptionally stable redox-active supramolecular protein assemblies with emergent properties, Proc. Natl. Acad. Sci. USA 111, 2897-2902 (2014). [PDF]

A. Medina-Morales, A. Perez, J.D. Brodin, F. A. Tezcan. In Vitro and Cellular Self-Assembly of a Zn-Binding Protein Cryptand via Templated Disulfide Bonds, J. Am. Chem. Soc. 135 12013-12022 (2013). [PDF]

F. A. Tezcan. “Metal-Directed and Templated Assembly of Protein Superstructures and Cages”, in “Coordination Chemistry in Protein Cages”, Takafumi Ueno and Yoshi Watanabe (editors), Wiley & Sons (2013). [PDF]

S. J. Smith*, K. Du*, R. J. Radford, F. A. Tezcan.  Functional, metal-based cross linkers for α-helix induction in short peptides, Chem. Sci. 4, 3740-3747 (2013). [PDF]

D. J. E. Huard, K. M. Kane, F. A. Tezcan.  Re-engineering protein interfaces yields copper-inducible ferritin cage assembly, Nat. Chem. Biol. 9, 169-176 (2013). [PDF]

L. E. Roth and F. A. Tezcan. ATP-Uncoupled, Six-Electron Photoreduction of Hydrogen Cyanide to Methane by the Molybdenum-Iron Protein, J. Am. Chem. Soc. 134, 8416-8419 (2012). [PDF]

J.D. Brodin, X. Ambroggio, C. Tang, K. Parent, T. Baker, F.A. Tezcan.  Metal-directed, chemically tunable assembly of one-, two- and three-dimensional crystalline protein arrays, Nat. Chem. 4, 375-382 (2012). [PDF]

L. E. Roth and F. A. Tezcan. Light-Driven Uncoupling of Nitrogenase Catalysis from ATP Hydrolysis, Chem. Cat. Chem. 3, 1549-1555 (2011). [PDF]

E. N. Salgado, J. D. Brodin, M. M. To, F. A. Tezcan. Templated Construction of a Zn-Selective Protein Dimerization Motif , Inorg. Chem. 50, 6323-6329 (2011).  [PDF]

R. J. Radford, M. Lawrenz, P. C. Nguyen, J. A. McCammon, F. A. Tezcan. Porous Protein Frameworks with Unsaturated Metal Centers in Sterically Encumbered Coordination Sites. Chem. Commun., 47, 313-315 (2011). [PDF]

R. J. Radford, J. D. Brodin, E. N. Salgado, F. A. Tezcan.  Expanding the Utility of Proteins as Platforms for Coordination Chemistry, Coord. Chem. Rev. 255, 790-803 (2011). [PDF]

L. E. Roth and F. A. Tezcan. “X-ray Crystallography”, in “Nitrogen Fixation – Methods and Protocols”, M. W. Ribbe (editor), Springer/Humana Press (2011).

  L. E. Roth, J. C. Nguyen, F. A. Tezcan.  ATP- and Iron Protein-Independent Activation of Nitrogenase Catalysis by Light, J. Am.Chem. Soc., 132, 13672-13674 (2010). [PDF]

T. W. Ni, F. A. Tezcan.  Structural Characterization of a Microperoxidase Inside a Metal-Directed Protein Cage.  Angew. Chem. Int. Ed., 49, 7014-7018 (2010). [PDF]

R. J. Radford, P. C. Nguyen, F. A. Tezcan,  Modular and Versatile Hybrid Coordination Motifs on α-Helical Protein Surfaces.  Inorg. Chem., 49, 7106-7115 (2010). [PDF]

J. D. Brodin, A. Medina-Morales, T. Ni, E.N. Salgado, X.I. Ambroggio, F.A. Tezcan.  Evolution of Metal Selectivity in Templated Protein Interfaces.  J. Am. Chem. Soc., 132, 8610-8617 (2010). [PDF]

R. J. Radford, P. C. Nguyen, T. B. Ditri, J. S. Figureroa, F. A. Tezcan.  Controlled Protein Dimerization through Hybrid Coordination Motifs.  Inorg. Chem., 49, 4362-4369 (2010). [PDF]

E. N. Salgado, R. J. Radford, F. A. Tezcan.  Metal-Directed Protein Self-Assembly.  Acc. Chem. Res., 43, 661-672 (2010). [PDF]

E. N. Salgado, X.I. Ambroggio, J. D. Brodin, R. A. Lewis, B. Kuhlman, F. A. Tezcan.  Metal Templated Design of Protein Interfaces.  Proc Natl Acad Sci USA, 107, 1827–1832 (2010). [PDF]

R. J. Radford, F.A. Tezcan.  A Superprotein Triangle Driven by Nickel(II) Coordination: Exploiting Non-Natural Metal Ligands in Protein Self-Assembly.  J. Am. Chem. Soc., 131, 9136-9137 (2009). [PDF]

E. N. Salgado, R. A. Lewis, S. Mossin, A. L. Rheingold, F. A. Tezcan.  Control of Protein Oligomerization Symmetry by Metal Coordination: C-2 and C-3 Symmetrical Assemblies through Cu-II and Ni-II Coordination.  Inorg. Chem., 48, 2726–2728 (2009). [PDF]

E. N. Salgado, R. A. Lewis, J. Faraone-Mennella, F. A. Tezcan.  Metal-Mediated Self-Assembly of Protein Superstructures: Influence of Secondary Interactions on Protein Oligomerization and Aggregation.  J. Am. Chem. Soc., 130, 6082–6084 (2008). [PDF]

E. N. Salgado, J. Faraone-Mennella, F. A. Tezcan.  Controlling Protein-Protein Interactions by Metal Coordination Chemistry: Assembly of a 16-Helix-Bundle Protein.  J. Am. Chem. Soc., 129, 13374-13375 (2007). [PDF]

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