{"id":869,"date":"2024-09-19T00:00:37","date_gmt":"2024-09-19T07:00:37","guid":{"rendered":"http:\/\/tezcan.ucsd.edu\/?page_id=869"},"modified":"2026-03-04T11:05:34","modified_gmt":"2026-03-04T19:05:34","slug":"publications-2","status":"publish","type":"page","link":"http:\/\/tezcan.ucsd.edu\/index.php\/publications-2\/","title":{"rendered":"Publications"},"content":{"rendered":"\n

V.H. Eng, S.M. Narehood, Y. Li, M. Gasc\u00f3n, A.M. Hoffnagle, A.A. Shiau, M. Semonis, M.T.Green, R.D Britt, F.A. Tezcan. Computational Design of a Highly Stable Dicopper Catechol Oxidase, J. Am. Chem. Soc.<\/em>\u00a0(2026).\u00a0[PDF]<\/a><\/strong><\/p>\n\n\n\n

A.M. Hoffnagle, R.A. Herold, C-Y Tsai, A.A. Shiau, R.D Britt, F.A. Tezcan. De Novo<\/em> Design of a Metalloprotein with a Synthetically Inspired Dinuclear Paddlewheel Coordination Motif, J. Am. Chem. Soc.<\/em> (2025). [PDF]<\/a><\/strong><\/p>\n\n\n\n

V.H. Eng, M. Gasc\u00f3n, A. Kakkis, F.A. Tezcan. Design of a protein scaffold with a selective, Bi-containing heterodinuclear metal coordination motif, J. Inorg. Biochem.<\/em> (2025). [PDF]<\/a><\/strong><\/p>\n\n\n\n

V. Nanda, J. Siess, B.P. Jagilinki, R.M. Hazen, S.C.L. Kamerlin, R. Koder, D. Noy, J. Silberg, F.A. Tezcan, R. Ulijn, N. Yee, P. Falkowski. On the emergence of metabolism: the evolution of proteins that powered life, Phil. Trans. R. Soc. B<\/em> (2025). [PDF]<\/a><\/strong><\/p>\n\n\n\n

H.T. Chiang, Z. Zhang, K. Vaddi, F.A. Tezcan, L.D. Pozzo. Efficient analysis of small-angle scattering curves for large biomolecular assemblies using Monte Carlo methods, J. Appl. Cryst. <\/em>(2025). [PDF]<\/a><\/strong><\/p>\n\n\n\n

A.M. Hoffnagle, S. Srisantitham, M. Neeley, C. Tsai, F.A.Tezcan. A De Novo<\/em> Designed Protein with Versatile Metal Binding and Tunable Hydrolytic Activity, Biochemistry<\/em> (2025). [PDF]<\/a><\/strong><\/p>\n\n\n\n

B.D. Cook, S.M. Narehood, K.L. McGuire, Y. Li, F.A. Tezcan, M.A. Herzik Jr. Preparation of oxygen-sensitive proteins for high-resolution cryoEM structure determination using blot-free vitrification, Nat. Commun.<\/em> (2025). [PDF]<\/a><\/strong><\/p>\n\n\n\n

S. Srisantitham, A.L. Walker, U. Markerl*, F.A.Tezcan*. De Novo Design of Proteins for Autocatalytic Isopeptide Bond Formation, J. Am. Chem. Soc.<\/em> (2025). [PDF]<\/a><\/strong><\/p>\n\n\n\n

Z. Zhang, H.T. Chiang, Y. Xia, N. Avakyan, R.R. Sonani, F. Wang, E.H. Egelman, J.J. De Yoreo, L.D. Pozzo, F.A. Tezcan. Design of light- and chemically responsive protein assemblies through host-guest interactions, Chem<\/em> (2025). [PDF]<\/a><\/strong><\/p>\n\n\n\n

Y. Li, J. Zhu, Z. Zhang, J. Wei, F. Wang, G. Meisl, T.P.J. Knowles, E.H. Egelman, F.A. Tezcan. Transforming an ATP-dependent enzyme into a dissipative, self-assembling system, Nat. Chem. Biol. <\/em>(2025). [PDF]<\/a><\/strong><\/p>\n\n\n\n

S.M. Narehood, B.D. Cook, S. Srisantitham, V.H. Eng, A.A. Shiau, K.L. McGuire, R.D. Britt, M.A. Herzik Jr, F.A. Tezcan. Structural basis for the conformational protection of nitrogenase from O2<\/sub>, Nature <\/em>(2025). [PDF]<\/a><\/strong><\/p>\n\n\n\n

S. Vijayakumar*, R.G. Alberstein*, Z. Zhang*, Y. Lu, A. Chan, C.E. Wahl, J.S. Ha, D.E. Hunka, G.R. Boss, M.J. Sailor, F.A. Tezcan. Designed 2D protein crystals as dynamic molecular gatekeepers for a solid-state device, Nat. Commun.<\/em> (2024). [PDF]<\/a><\/strong><\/p>\n\n\n\n

K. Han, Z. Zhang, F.A. Tezcan. Spatially Patterned, Porous Protein Crystals as Multifunctional Materials, J. Am. Chem. Soc.<\/em> (2023). [PDF]<\/a><\/strong><\/p>\n\n\n\n

A.M. Hoffnagle, F.A. Tezcan. Atomically Accurate Design of Metalloproteins with Predefined Coordination Geometries, J. Am. Chem. Soc.<\/em> (2023). [PDF]<\/a><\/strong><\/p>\n\n\n\n

R.G. Alberstein*, J.L. Prelesnik*, E. Nakouzi, S. Zhang, J.J. De Yoreo, J. Pfaendtner, F.A. Tezcan, C.J. Mundy. Discrete Orientations of Interfacial Waters Direct Crystallization of Mica-Binding Proteins, J. Phys. Chem. Lett.<\/em> (2023). [PDF]<\/a><\/strong><\/p>\n\n\n\n

L. Spiegelman, A. Bahn-Suh, E.T. Monta\u00f1o, L. Zhang, G.L. Hura, K.A. Patras, A. Kumar, F.A. Tezcan, V. Nizet, S.E. Tsutakawa, P. Ghosh. Strengthening of enterococcal biofilms by Esp, PLoS pathogens<\/em> (2022). [PDF]<\/a><\/strong><\/p>\n\n\n\n

H.L. Rutledge, M.J. Field, J. Rittle, M.T. Green, F.A. Tezcan. Role of Serine Coordination in the Structural and Functional Protection of the Nitrogenase P-Cluster, J. Am. Chem. Soc.<\/em> (2022). [PDF]<\/a><\/strong><\/p>\n\n\n\n

T.S. Choi, F.A. Tezcan. Design of a Flexible, Zn-Selective Protein Scaffold that Displays Anti-Irving\u2212Williams Behavior,J. Am. Chem. Soc.<\/em> (2022). [PDF]<\/a><\/strong><\/p>\n\n\n\n

A.M. Hoffnagle, V.H. Eng, U. Markel, F.A. Tezcan. Computationally Guided Redesign of a Heme-free Cytochrome with Native-like Structure and Stability, Biochemistry<\/em> (2022). [PDF]<\/a><\/strong><\/p>\n\n\n\n

H.L. Rutledge, B.D. Cook, H.P.M. Nguyen, M.A. Herzik Jr., F.A. Tezcan. Structures of the nitrogenase complex prepared under catalytic turnover conditions, Science <\/em>(2022). [PDF]<\/a><\/strong> [Free access]<\/a><\/strong><\/p>\n\n\n\n

K. Han*, Y. Na*, L. Zhang, F.A. Tezcan. Dynamic, Polymer-Integrated Crystals for Efficient, Reversible Protein Encapsulation, J. Am. Chem. Soc.<\/em> (2022). [PDF]<\/a><\/strong><\/p>\n\n\n\n

A. Kakkis, E. Golub, T.S. Choi, F.A. Tezcan. Redox- and metal-directed structural diversification in designed metalloprotein assemblies, Chem. Commun. <\/em>(2022). [PDF]<\/a><\/strong><\/p>\n\n\n\n

T.S. Choi, F.A. Tezcan. Overcoming universal restrictions on metal selectivity by protein design, Nature <\/em>(2022). [PDF]<\/a><\/strong><\/p>\n\n\n\n

J. Zhu*, L. Samperisi*, M. Kalaj, J.A. Chiong, J.B. Bailey, Z. Zhang, C. Yu, R.E. Sikma, X. Zou, S.M. Cohen, Z. Huang, F.A. Tezcan. Metal-hydrogen-pi-bonded organic frameworks, Dalton Trans.<\/em> (2022). [PDF]<\/a><\/strong><\/p>\n\n\n\n

J. Zhu*, N. Avakyan*, A. Kakkis, A.M. Hoffnagle, K. Han, Y. Li, Z. Zhang, T.S. Choi, Y. Na, C. Yu, F.A. Tezcan. Protein assembly by design, Chem. Rev.<\/em> (2021). [PDF]<\/a><\/strong><\/p>\n\n\n\n

J.L. Prelesnik*, R.G. Alberstein*, S. Zhang, H. Pyles, D. Baker, J. Pfaendtner, J.J. De Yoreo, F.A. Tezcan, R.C. Remsing, C.J. Mundy. Ion-dependent protein\u2013surface interactions from intrinsic solvent response, Proc. Natl. Acad. Sci. USA<\/em>(2021). [PDF]<\/a><\/strong><\/p>\n\n\n\n

R.H. Subramanian, J. Zhu, J.B. Bailey, J.A. Chiong, Y. Li, E. Golub, F.A. Tezcan. Design of metal-mediated protein assemblies via hydroxamic acid functionalities, Nat. Protoc.<\/em> (2021). [PDF]<\/a><\/strong><\/p>\n\n\n\n

K. Han, J.B. Bailey, L. Zhang, F.A. Tezcan. Anisotropic Dynamics and Mechanics of Macromolecular Crystals Containing Lattice-Patterned Polymer Networks, J. Am. Chem. Soc.<\/em> (2020). [PDF]<\/a><\/strong><\/p>\n\n\n\n

J.B. Bailey, F.A. Tezcan. Tunable and Cooperative Thermomechanical Properties of Protein\u2013Metal\u2013Organic Frameworks,J. Am. Chem. Soc.<\/em> (2020). [PDF]<\/a><\/strong><\/p>\n\n\n\n

A. Kakkis, D. Gagnon, J. Esselborn, R.D. Britt, F.A. Tezcan. Metal-Templated Design of Chemically Switchable Protein Assemblies with High-Affinity Coordination Sites, Angew. Chem. Int. Ed.<\/em> (2020). [PDF]<\/a><\/strong><\/p>\n\n\n\n

K.C. Bentz, K. Gnanasekaran, J.B. Bailey, S. Ayala, F.A. Tezcan, N.C. Gianneschi, S.M. Cohen. Inside polyMOFs: layered structures in polymer-based metal\u2013organic frameworks, Chem. Sci.<\/em> (2020). [PDF]<\/a><\/strong><\/p>\n\n\n\n

R. Subramanian, Y. Suzuki, L. Tallorin, S. Sahu, M.P. Thompson, N.C. Gianneschi, M.D. Burkart, F.A. Tezcan. Enzyme-Directed Functionalization of Designed, Two-Dimensional Protein Lattices, Biochemistry<\/em> (2020). [PDF]<\/a><\/strong><\/p>\n\n\n\n

J.A. Chiong*, J. Zhu*, J.B. Bailey*, M. Kalaj, R. Subramanian, W. Xu, S.M. Cohen, F.A. Tezcan. An Exceptionally Stable Metal-Organic Framework Constructed from Chelate-based Metal-Organic Polyhedra, J. Am. Chem. Soc.<\/em> (2020). [PDF]<\/a><\/strong><\/p>\n\n\n\n

S. Zhang*, R.G. Alberstein*, J.J. De Yoreo, F.A. Tezcan. Assembly of a patchy protein into variable 2D lattices via tunable, multiscale interactions, Nat. Commun.<\/em> (2020). [Preprint]<\/a> [PDF]<\/a><\/strong><\/p>\n\n\n\n

H.L. Rutledge, F.A. Tezcan. Electron Transfer in Nitrogenase, Chem. Rev.<\/em> (2020). [PDF]<\/a><\/strong><\/p>\n\n\n\n

E. Golub, R.H. Subramanian, J. Esselborn, R.G. Alberstein, J.B. Bailey, J.A. Chiong, X. Yan, T. Booth, T.S. Baker, F.A. Tezcan. Constructing protein polyhedra via orthogonal chemical interactions, Nature <\/em>(2020). [PDF]<\/a><\/strong><\/p>\n\n\n\n

H.L Rutledge, J. Rittle, L.M. Williamson, W.A. Xu, D.M. Gagnon, F.A. Tezcan. Redox-dependent metastability of the nitrogenase P-cluster, J. Am. Chem. Soc. <\/em>(2019). [PDF]<\/a><\/strong><\/p>\n\n\n\n

J. Rittle, M.J. Field, M.T. Green, F.A. Tezcan. An efficient, step-economical strategy for the design of functional metalloproteins, Nat. Chem. <\/em>(2019). [PDF]<\/a><\/strong><\/p>\n\n\n\n

L.A. Churchfield, F.A. Tezcan. Design and Construction of Functional Supramolecular Metalloprotein Assemblies, Acc. Chem. Res. <\/em>(2019). [PDF]<\/a><\/strong><\/p>\n\n\n\n

R.H. Subramanian*, S.J. Smith*, R.G. Alberstein, J.B. Bailey, L. Zhang, G. Cardone, L. Suominen, M. Chami, H. Stahlberg, T.S. Baker, F.A. Tezcan. Self-Assembly of a Designed Nucleoprotein Architecture through Multimodal Interactions, ACS Cent. Sci. <\/em>(2018). [PDF]<\/a><\/strong><\/p>\n\n\n\n

L.A. Churchfield, R.G. Alberstein, L.M. Williamson, F.A. Tezcan. Determining the Structural and Energetic Basis of Allostery in a De Novo<\/em> Designed Metalloprotein Assembly, J. Am. Chem. Soc. <\/em>(2018). [PDF]<\/a><\/strong><\/p>\n\n\n\n

L. Zhang, J.B. Bailey, R.H. Subramanian, F.A. Tezcan. Hyperexpandable, self-healing macromolecular crystals with integrated polymer networks, Nature <\/em>(2018). [PDF]<\/a><\/strong><\/p>\n\n\n\n

R. Alberstein, Y. Suzuki, F. Paesani, F.A. Tezcan. Engineering the entropy-driven free-energy landscape of a dynamic nanoporous protein assembly, Nat. Chem. <\/em>(2018). [PDF]<\/a><\/strong><\/p>\n\n\n\n

W.J. Song, J. Yu, F.A. Tezcan. Importance of scaffold flexibility\/rigidity in the design and directed evolution of artificial metallo-\u03b2-lactamases, J. Am. Chem. Soc. <\/em>(2017). [PDF]<\/a><\/strong><\/p>\n\n\n\n

J.B. Bailey, L. Zhang, J.A. Chiong, S. Ahn, F.A. Tezcan. Synthetic Modularity of Protein\u2013Metal\u2013Organic Frameworks, J. Am. Chem. Soc. <\/em>(2017). [PDF]<\/a><\/strong><\/p>\n\n\n\n

L.A. Churchfield, A. George, F.A. Tezcan. Repurposing proteins for new bioinorganic functions, Essays Biochem. <\/em>(2017). [PDF]<\/a><\/strong><\/p>\n\n\n\n

S.A. Chabolla, C.W. Machan, J. Yin, E.A. Dellamary, S. Sahu, N.C. Gianneschi, M.K.Gilson, F.A. Tezcan, C.P. Kubiak. Bio-inspired CO2 reduction by a rhenium tricarbonyl bipyridine-based catalyst appended to amino acids and peptidic platforms: incorporating proton relays and hydrogen-bonding functional groups, Farad. Discuss. <\/em>(2017). [PDF]<\/a><\/strong><\/p>\n\n\n\n

F.E.H. Katz, X. Shi, C.P. Owens, S. Joseph, F.A. Tezcan. Determination of nucleoside triphosphatase activities from measurement of true inorganic phosphate in the presence of labile phosphate compounds, Anal. Biochem. <\/em>(2017). [PDF]<\/a><\/strong><\/p>\n\n\n\n

L.A. Churchfield, F. Medina-Morales, J.D. Brodin, A. Perez, F.A. Tezcan. De Novo Design of an Allosteric Metalloprotein Assembly with Strained Disulfide Bonds, J. Am. Chem. Soc. <\/em>(2016). [PDF]<\/a><\/strong><\/p>\n\n\n\n

C.P. Owens, F.E.H. Katz, C.H. Carter, V.F. Oswald, F.A. Tezcan. Tyrosine-coordinated P-cluster in G. diazotrophicus nitrogenase: Evidence for the importance of O-based ligands in conformationally gated electron transfer, J. Am. Chem. Soc. <\/em>(2016). [PDF]<\/a><\/strong><\/p>\n\n\n\n

J.B. Bailey, R.H. Subramanian, L.A. Churchfield, F.A. Tezcan. Chapter Eleven \u2013 Metal-Directed Design of Supramolecular Protein Assemblies, Meth. Enzym. <\/em>(2016). [PDF]<\/a><\/strong><\/p>\n\n\n\n

F.E.H. Katz, C.P. Owens, F.A. Tezcan. Electron Transfer Reactions in Biological Nitrogen Fixation, Isr. J. Chem. <\/em>(2016). [PDF]<\/a><\/strong><\/p>\n\n\n\n

Y. Suzuki, G. Cardone, D. Restrepo, P.D. Zavattieri, T.S. Baker, F.A. Tezcan. Self-assembly of coherently dynamic, auxetic, two-dimensional protein crystals, Nature <\/em>(2016). [PDF]<\/a><\/strong><\/p>\n\n\n\n

S.J. Smith, R.J. Radford, R.H. Subramanian, B.R. Barnett, J.S. Figueroa, F.A. Tezcan. Tunable helicity, stability and DNA-binding properties of short peptides with hybrid metal coordination motifs, Chem. Sci. <\/em>(2016). [PDF]<\/a><\/strong><\/p>\n\n\n\n

C.P. Owens, F.E.H. Katz, C.H. Carter, M.A. Luca, F.A. Tezcan. Evidence for Functionally Relevant Encounter Complexes in Nitrogenase Catalysis, J. Am. Chem. Soc. <\/em>(2015). [PDF]<\/a><\/strong><\/p>\n\n\n\n

P.A. Sontz*, J.B. Bailey*, S. Ahn, F.A. Tezcan. A Metal Organic Framework with Spherical Protein Nodes: Rational Chemical Design of 3D Protein Crystals, J. Am. Chem. Soc.<\/em> (2015). [PDF]<\/a><\/strong><\/p>\n\n\n\n

J.D. Brodin*, S.J. Smith*, J.R. Carr, F.A. Tezcan. Designed, Helical Protein Nanotubes with Variable Diameters from a Single Building Block, J. Am. Chem. Soc. <\/em>(2015). [PDF]<\/a><\/strong><\/p>\n\n\n\n

F.A. Tezcan, J.T. Kaiser, J.B. Howard, D.C. Rees. Structural Evidence for Asymmetrical Nucleotide Interactions in Nitrogenase, J. Am. Chem. Soc. <\/em>(2014). [PDF]<\/a><\/strong><\/p>\n\n\n\n

W.J. Song, F.A. Tezcan. A designed supramolecular protein assembly with in vivo enzymatic activity, Science 346<\/strong><\/em>, 1525-1528 (2014). [PDF]<\/a><\/strong><\/p>\n\n\n\n

C.W. Machan, S.A. Chabolla, J. Yin, M.K. Gilson, F.A. Tezcan, C.P. Kubiak. Supramolecular Assembly Promotes the Electrocatalytic Reduction of Carbon Dioxide by Re(I) Bipyridine Catalysts at a Lower Overpotential, J. Am. Chem. Soc. 136<\/strong><\/em>, 14598-14607 (2014). [PDF]<\/a><\/strong><\/p>\n\n\n\n

S.A. Chabolla, E.A. Dellamary, C.W. Machan, F.A. Tezcan, C.P. Kubiak. Combined steric and electronic effects of positional substitution on dimethyl-bipyridine rhenium(I)tricarbonyl electrocatalysts for the reduction of CO2,<\/sub> Inorg. Chim. Acta 422<\/strong><\/em>, 109-113 (2014). [PDF]<\/a><\/strong><\/p>\n\n\n\n

P.A. Sontz*, W.J. Song*, F. A. Tezcan. Interfacial metal coordination in engineered protein and peptide assemblies, Curr. Opin. Chem. Biol. 19<\/strong><\/em>, 42-49 (2014). [PDF]<\/a><\/strong><\/p>\n\n\n\n

W.J. Song*, P.A. Sontz*, X.I. Ambroggio, F.A. Tezcan. Metals in protein-protein interfaces, Annu. Rev. Biophys. <\/em> 43<\/em><\/strong>, 409-431 (2014). [PDF]<\/a><\/strong><\/p>\n\n\n\n

J.D. Brodin, J.R. Carr, P.A. Sontz, F.A. Tezcan. Exceptionally stable redox-active supramolecular protein assemblies with emergent properties, Proc. Natl. Acad. Sci. USA 111<\/strong>, 2897-2902 <\/em>(2014). [PDF]<\/a><\/strong><\/p>\n\n\n\n

A. Medina-Morales, A. Perez, J.D. Brodin, F. A. Tezcan. In Vitro and Cellular Self-Assembly of a Zn-Binding Protein Cryptand via Templated Disulfide Bonds, J. Am. Chem. Soc. 135<\/strong><\/em> 12013-12022 (2013). [PDF]<\/a><\/strong><\/p>\n\n\n\n

F. A. Tezcan. \u201cMetal-Directed and Templated Assembly of Protein Superstructures and Cages\u201d, in \u201cCoordination Chemistry in Protein Cages\u201d, Takafumi Ueno and Yoshi Watanabe (editors), Wiley & Sons (2013). [PDF]<\/a><\/strong><\/p>\n\n\n\n

S. J. Smith*, K. Du*, R. J. Radford, F. A. Tezcan.  Functional, metal-based cross linkers for \u03b1-helix induction in short peptides, Chem. Sci. 4<\/strong><\/em>, 3740-3747 (2013). [PDF]<\/a><\/strong><\/p>\n\n\n\n

D. J. E. Huard, K. M. Kane, F. A. Tezcan.  Re-engineering protein interfaces yields copper-inducible ferritin cage assembly, Nat. Chem. Biol. 9<\/strong><\/em>, 169-176 (2013). [PDF]<\/a><\/strong><\/p>\n\n\n\n

L. E. Roth and F. A. Tezcan. ATP-Uncoupled, Six-Electron Photoreduction of Hydrogen Cyanide to Methane by the Molybdenum-Iron Protein, J. Am. Chem. Soc. 134<\/strong><\/em>, 8416-8419 (2012). [PDF]<\/a><\/strong><\/p>\n\n\n\n

J.D. Brodin, X. Ambroggio, C. Tang, K. Parent, T. Baker, F.A. Tezcan.  Metal-directed, chemically tunable assembly of one-, two- and three-dimensional crystalline protein arrays, Nat. Chem. 4<\/strong><\/em>, 375-382 (2012). [PDF]<\/a><\/strong><\/p>\n\n\n\n

L. E. Roth and F. A. Tezcan. Light-Driven Uncoupling of Nitrogenase Catalysis from ATP Hydrolysis, Chem. Cat. Chem. 3<\/strong><\/em>, 1549-1555 (2011). [PDF]<\/a><\/strong><\/p>\n\n\n\n

E. N. Salgado, J. D. Brodin, M. M. To, F. A. Tezcan. Templated Construction of a Zn-Selective Protein Dimerization Motif, Inorg. Chem. 50<\/strong><\/em>, 6323-6329 (2011).  [PDF]<\/a><\/strong><\/p>\n\n\n\n

R. J. Radford, M. Lawrenz, P. C. Nguyen, J. A. McCammon, F. A. Tezcan. Porous Protein Frameworks with Unsaturated Metal Centers in Sterically Encumbered Coordination Sites. Chem. Commun.<\/em>, 47<\/strong>, 313-315 (2011). [PDF]<\/strong><\/a><\/p>\n\n\n\n

R. J. Radford, J. D. Brodin, E. N. Salgado, F. A. Tezcan.  Expanding the Utility of Proteins as Platforms for Coordination Chemistry, Coord. Chem. Rev. <\/em>255<\/strong>, 790-803 (2011). [PDF]<\/a><\/strong><\/p>\n\n\n\n

L. E. Roth and F. A. Tezcan. \u201cX-ray Crystallography\u201d, in \u201cNitrogen Fixation \u2013 Methods and Protocols\u201d, M. W. Ribbe (editor), Springer\/Humana Press (2011).<\/p>\n\n\n\n

L. E. Roth, J. C. Nguyen, F. A. Tezcan.  ATP- and Iron Protein-Independent Activation of Nitrogenase Catalysis by Light, J. Am. Chem. Soc., <\/em>132<\/strong>, 13672-13674 (2010). [PDF]<\/strong><\/a><\/p>\n\n\n\n

T. W. Ni, F. A. Tezcan.  Structural Characterization of a Microperoxidase Inside a Metal-Directed Protein Cage.  Angew. Chem. Int. Ed.<\/em>, 49<\/strong>, 7014-7018 (2010). [PDF]<\/strong><\/a><\/p>\n\n\n\n

R. J. Radford, P. C. Nguyen, F. A. Tezcan,  Modular and Versatile Hybrid Coordination Motifs on \u03b1-Helical Protein Surfaces.  Inorg. Chem.,<\/em> 49<\/strong>, 7106-7115 (2010). [PDF]<\/strong><\/a><\/p>\n\n\n\n

J. D. Brodin, A. Medina-Morales, T. Ni, E.N. Salgado, X.I. Ambroggio, F.A. Tezcan.  Evolution of Metal Selectivity in Templated Protein Interfaces.  J. Am. Chem. Soc.<\/em>, 132<\/strong>, 8610-8617 (2010). [PDF]<\/strong><\/a><\/p>\n\n\n\n

R. J. Radford, P. C. Nguyen, T. B. Ditri, J. S. Figureroa, F. A. Tezcan.  Controlled Protein Dimerization through Hybrid Coordination Motifs.  Inorg. Chem.<\/em>, 49<\/strong>, 4362-4369 (2010). [PDF]<\/strong><\/a><\/p>\n\n\n\n

E. N. Salgado, R. J. Radford, F. A. Tezcan.  Metal-Directed Protein Self-Assembly.  Acc. Chem. Res.<\/em>, 43<\/strong>, 661-672 (2010). [PDF]<\/strong><\/a><\/p>\n\n\n\n

E. N. Salgado, X.I. Ambroggio, J. D. Brodin, R. A. Lewis, B. Kuhlman, F. A. Tezcan.  Metal Templated Design of Protein Interfaces.  Proc Natl Acad Sci USA<\/em>, 107<\/strong>, 1827\u20131832 (2010). [PDF]<\/strong><\/a><\/p>\n\n\n\n

R. J. Radford, F.A. Tezcan.  A Superprotein Triangle Driven by Nickel(II) Coordination: Exploiting Non-Natural Metal Ligands in Protein Self-Assembly.  J. Am. Chem. Soc.<\/em>, 131<\/strong>, 9136-9137 (2009). [PDF]<\/strong><\/a><\/p>\n\n\n\n

E. N. Salgado, R. A. Lewis, S. Mossin, A. L. Rheingold, F. A. Tezcan.  Control of Protein Oligomerization Symmetry by Metal Coordination: C-2 and C-3 Symmetrical Assemblies through Cu-II and Ni-II Coordination.  Inorg. Chem.<\/em>, 48<\/strong>, 2726\u20132728 (2009). [PDF]<\/strong><\/a><\/p>\n\n\n\n

E. N. Salgado, R. A. Lewis, J. Faraone-Mennella, F. A. Tezcan.  Metal-Mediated Self-Assembly of Protein Superstructures: Influence of Secondary Interactions on Protein Oligomerization and Aggregation.  J. Am. Chem. Soc.<\/em>, 130<\/strong>, 6082\u20136084 (2008). [PDF]<\/strong><\/a><\/p>\n\n\n\n

E. N. Salgado, J. Faraone-Mennella, F. A. Tezcan.  Controlling Protein-Protein Interactions by Metal Coordination Chemistry: Assembly of a 16-Helix-Bundle Protein.  J. Am. Chem. Soc.<\/em>, 129<\/strong>, 13374-13375 (2007). [PDF]<\/strong><\/a><\/p>\n\n\n\n

<\/div>\n","protected":false},"excerpt":{"rendered":"

V.H. Eng, S.M. Narehood, Y. Li, M. Gasc\u00f3n, A.M. Hoffnagle, A.A. Shiau, M. Semonis, M.T.Green, R.D Britt, F.A. Tezcan. Computational Design of a Highly Stable Dicopper Catechol Oxidase, J. Am. Chem. Soc.\u00a0(2026).\u00a0[PDF] A.M. Hoffnagle, R.A. Herold, C-Y Tsai, A.A. Shiau, R.D Britt, F.A. Tezcan. De Novo Design of a Metalloprotein with a Synthetically Inspired Dinuclear Paddlewheel … <\/p>\n

Read more “Publications”<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-869","page","type-page","status-publish","hentry"],"featured_media_urls":[],"_links":{"self":[{"href":"http:\/\/tezcan.ucsd.edu\/index.php\/wp-json\/wp\/v2\/pages\/869"}],"collection":[{"href":"http:\/\/tezcan.ucsd.edu\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/tezcan.ucsd.edu\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/tezcan.ucsd.edu\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"http:\/\/tezcan.ucsd.edu\/index.php\/wp-json\/wp\/v2\/comments?post=869"}],"version-history":[{"count":37,"href":"http:\/\/tezcan.ucsd.edu\/index.php\/wp-json\/wp\/v2\/pages\/869\/revisions"}],"predecessor-version":[{"id":1424,"href":"http:\/\/tezcan.ucsd.edu\/index.php\/wp-json\/wp\/v2\/pages\/869\/revisions\/1424"}],"wp:attachment":[{"href":"http:\/\/tezcan.ucsd.edu\/index.php\/wp-json\/wp\/v2\/media?parent=869"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}